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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinitis pigmentosa (RP)
ncRNA name IMPDH1 shRNA
ncRNA Category shRNA
Disease name retinitis pigmentosa (RP)
Species Mus musculus
Tissues/Cell_line retinas
Methods shRNA knockdown, qRT-PCR, Western blot, immunostaining
Expression pattern associated
Functional description The use of rAAV2/5 vectors expressing shRNA targeting mutant IMPDH1 prevents photoreceptor degeneration, and preserves synaptic connectivity in a mouse model of RP10.
PubMed ID 20238059
Year 2010
Title Protection of photoreceptors in a mouse model of RP10.
Drug-related ncRNA NA

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